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1.
Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
Proc Natl Acad Sci U S A
; 119(18): e2201646119, 2022 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35507892
2.
Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity.
Int J Mol Sci
; 24(6)2023 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982602
3.
ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia.
Int J Mol Sci
; 24(6)2023 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982689
4.
Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice.
Int J Mol Sci
; 24(13)2023 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37446191
5.
Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions.
J Biol Chem
; 294(43): 15836-15849, 2019 10 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31495784
6.
Nanodisc scaffold peptide (NSPr) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs.
Arch Biochem Biophys
; 691: 108518, 2020 09 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32735863
7.
Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer.
Arch Biochem Biophys
; 671: 103-110, 2019 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31251920
8.
Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.
Am J Physiol Endocrinol Metab
; 315(3): E340-E356, 2018 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29533741
9.
Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
J Biol Chem
; 291(12): 6232-44, 2016 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26801614
10.
Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum.
J Biol Chem
; 290(39): 23464-77, 2015 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26198636
11.
Correction: Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma.
Biochem J
; 477(24): 4811, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33367592
12.
The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters.
Acta Biochim Biophys Sin (Shanghai)
; 48(11): 990-997, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27688150
13.
Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors.
Acta Biochim Biophys Sin (Shanghai)
; 48(11): 980-989, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27688151
14.
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aß1-42 clearance.
J Neurosci
; 34(43): 14484-501, 2014 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-25339759
15.
ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration.
Acta Biochim Biophys Sin (Shanghai)
; 47(12): 951-9, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26474739
16.
Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis.
Arterioscler Thromb Vasc Biol
; 33(9): 2081-7, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23846496
17.
Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase.
J Biol Chem
; 287(21): 17483-17492, 2012 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-22474282
18.
MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation.
Acta Biochim Biophys Sin (Shanghai)
; 45(11): 953-62, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24028971
19.
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Proc Natl Acad Sci U S A
; 107(7): 3081-6, 2010 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-20133765
20.
Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture.
J Neurosci Methods
; 367: 109437, 2022 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34890698