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1.

Stereoselective Synthesis and Biological Evaluation of C1-Epimeric and Desmethyl Monomeric Nuphar Analogues.

Li, Hui; Cooke, Timothy J; Korotkov, Alexander; Chapman, Charles W; Eastman, Alan; Wu, Jimmy.

J Org Chem ; 82(5): 2648-2655, 2017 03 03.

Artículo en Inglés | MEDLINE | ID: mdl-28164703

2.

Enantioselective Formal Syntheses of 11 Nuphar Alkaloids and Discovery of Potent Apoptotic Monomeric Analogues.

Li, Hui; Korotkov, Alexander; Chapman, Charles W; Eastman, Alan; Wu, Jimmy.

Angew Chem Int Ed Engl ; 55(10): 3509-13, 2016 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-26846359

3.

Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids.

Korotkov, Alexander; Li, Hui; Chapman, Charles W; Xue, Haoran; MacMillan, John B; Eastman, Alan; Wu, Jimmy.

Angew Chem Int Ed Engl ; 54(36): 10604-7, 2015 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-26205039

4.

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.

Stock, Nicholas; Volkots, Deborah; Stebbins, Karin; Broadhead, Alex; Stearns, Brian; Roppe, Jeffrey; Parr, Timothy; Baccei, Christopher; Bain, Gretchen; Chapman, Charles; Correa, Lucia; Darlington, Janice; King, Christopher; Lee, Catherine; Lorrain, Daniel S; Prodanovich, Pat; Santini, Angelina; Evans, Jilly F; Hutchinson, John H; Prasit, Peppi.

Bioorg Med Chem Lett ; 21(3): 1036-40, 2011 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-21211969

5.

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.

Stock, Nicholas; Baccei, Christopher; Bain, Gretchen; Chapman, Charles; Correa, Lucia; Darlington, Janice; King, Christopher; Lee, Catherine; Lorrain, Daniel S; Prodanovich, Pat; Santini, Angelina; Schaab, Kevin; Evans, Jilly F; Hutchinson, John H; Prasit, Peppi.

Bioorg Med Chem Lett ; 20(15): 4598-601, 2010 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-20566292

6.

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.

Stock, Nicholas; Baccei, Christopher; Bain, Gretchen; Broadhead, Alex; Chapman, Charles; Darlington, Janice; King, Christopher; Lee, Catherine; Li, Yiwei; Lorrain, Daniel S; Prodanovich, Pat; Rong, Haojing; Santini, Angelina; Zunic, Jasmine; Evans, Jilly F; Hutchinson, John H; Prasit, Peppi.

Bioorg Med Chem Lett ; 20(1): 213-7, 2010 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-19914828

7.

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.

Lorrain, Daniel S; Bain, Gretchen; Correa, Lucia D; Chapman, Charles; Broadhead, Alex R; Santini, Angelina M; Prodanovich, Pat; Darlington, Janice V; Hutchinson, John H; King, Christopher; Lee, Catherine; Baccei, Christopher; Li, Yiwei; Arruda, Jeannie M; Evans, Jilly F.

J Pharmacol Exp Ther ; 331(3): 1042-50, 2009 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-19749079

8.

5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.

Stock, Nicholas S; Bain, Gretchen; Zunic, Jasmine; Li, Yiwei; Ziff, Jeannie; Roppe, Jeffrey; Santini, Angelina; Darlington, Janice; Prodanovich, Pat; King, Christopher D; Baccei, Christopher; Lee, Catherine; Rong, Haojing; Chapman, Charles; Broadhead, Alex; Lorrain, Dan; Correa, Lucia; Hutchinson, John H; Evans, Jilly F; Prasit, Peppi.

J Med Chem ; 54(23): 8013-29, 2011 Dec 08.

Artículo en Inglés | MEDLINE | ID: mdl-22059882

9.

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.

Lorrain, Daniel S; Bain, Gretchen; Correa, Lucia D; Chapman, Charles; Broadhead, Alex R; Santini, Angelina M; Prodanovich, Patricia P; Darlington, Janice V; Stock, Nicholas S; Zunic, Jasmine; King, Christopher D; Lee, Catherine; Baccei, Christopher S; Stearns, Brian; Roppe, Jeffrey; Hutchinson, John H; Prasit, Peppi; Evans, Jilly F.

Eur J Pharmacol ; 640(1-3): 211-8, 2010 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-20519143

10.

5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).

Hutchinson, John H; Li, Yiwei; Arruda, Jeannie M; Baccei, Christopher; Bain, Gretchen; Chapman, Charles; Correa, Lucia; Darlington, Janice; King, Christopher D; Lee, Catherine; Lorrain, Dan; Prodanovich, Pat; Rong, Haojing; Santini, Angelina; Stock, Nicholas; Prasit, Peppi; Evans, Jilly F.

J Med Chem ; 52(19): 5803-15, 2009 Oct 08.

Artículo en Inglés | MEDLINE | ID: mdl-19739647

11.

Biocultural aspects of disease

Rothschild, Henry; Chapman, Charles F.

Louisiana; Academic Press; 1981. 653 p.

Monografía en Inglés | LILACS, SES-SP, SESSP-ISPROD, SES-SP, SESSP-ISACERVO | ID: biblio-1072944

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