Detalles de la búsqueda
1.
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein.
Immunity
; 53(5): 1095-1107.e3, 2020 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33128877
2.
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Nature
; 547(7664): 453-457, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28678785
3.
MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.
Proc Natl Acad Sci U S A
; 116(15): 7533-7542, 2019 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30898885
4.
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Nat Chem Biol
; 9(12): 840-848, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24161946
5.
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications.
Mol Cancer Ther
; 6(2): 404-17, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17308042
6.
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Mol Cancer Ther
; 5(2): 438-49, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16505119
7.
The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Mol Cancer Ther
; 5(10): 2549-55, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17041099
8.
Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Clin Cancer Res
; 11(3): 1294-301, 2005 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15709201
9.
Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Cancer Res
; 64(9): 3313-9, 2004 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15126375
10.
A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.
Cancer Res
; 62(22): 6434-7, 2002 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12438230
11.
Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Mol Cancer Ther
; 4(12): 1860-6, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16373701
12.
Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.
Mol Neuropsychiatry
; 2(2): 97-106, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27606323
13.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in ß-Cell Protection.
ACS Chem Biol
; 11(2): 363-74, 2016 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26640968
14.
Antifolate resistance in a HeLa cell line associated with impaired transport independent of the reduced folate carrier.
Clin Cancer Res
; 10(24): 8735-42, 2004 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15623659
15.
Lack of impact of the loss of constitutive folate receptor alpha expression, achieved by RNA Interference, on the activity of the new generation antifolate pemetrexed in HeLa cells.
Clin Cancer Res
; 10(23): 7986-93, 2004 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15585634
16.
HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ß-catenin in human iPSC-derived neuronal cells.
ACS Chem Biol
; 10(3): 883-90, 2015 Mar 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25546293
17.
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Cell Rep
; 10(5): 755-770, 2015 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25660025
18.
BCL2 blockade overcomes MCL1 resistance in multiple myeloma.
Leukemia
; 33(8): 2098-2102, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30816329
19.
The antifolates: evolution, new agents in the clinic, and how targeting delivery via specific membrane transporters is driving the development of a next generation of folate analogs.
Curr Opin Investig Drugs
; 11(12): 1409-23, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21154123
20.
Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability.
Oncologist
; 12(7): 808-15, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17673612