Detalles de la búsqueda
1.
Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors.
Molecules
; 25(8)2020 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32331470
2.
Cinnamides Target Leishmania amazonensis Arginase Selectively.
Molecules
; 25(22)2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33198198
3.
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.
Bioorg Med Chem
; 27(19): 115045, 2019 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31427145
4.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Bioorg Chem
; 89: 103020, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31185392
5.
A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.
Molecules
; 24(23)2019 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31795400
6.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1.
Sci Transl Med
; 15(726): eadh9902, 2023 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38091406
7.
Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Cell Chem Biol
; 28(5): 711-721.e8, 2021 05 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-33691122
8.
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation.
Eur J Med Chem
; 212: 112998, 2021 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33199154
9.
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents.
ACS Chem Neurosci
; 12(9): 1716-1736, 2021 05 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33890763
10.
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.
J Med Chem
; 64(14): 9960-9988, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34251197
11.
Amyloid ß fibril disruption by oleuropein aglycone: long-time molecular dynamics simulation to gain insight into the mechanism of action of this polyphenol from extra virgin olive oil.
Food Funct
; 11(9): 8122-8132, 2020 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32857079
12.
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents.
Eur J Med Chem
; 200: 112405, 2020 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32492595
13.
Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions.
ACS Chem Neurosci
; 11(12): 1791-1800, 2020 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32437601
14.
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents.
ACS Infect Dis
; 6(1): 100-113, 2020 01 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31661956
15.
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.
ACS Med Chem Lett
; 11(11): 2268-2276, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214839
16.
An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction.
Comput Biol Chem
; 83: 107105, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31473433
17.
A light in the dark: state of the art and perspectives in optogenetics and optopharmacology for restoring vision.
Future Med Chem
; 11(5): 463-487, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30907134
18.
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach.
Front Chem
; 7: 574, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31457006
19.
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.
Med Chem
; 15(7): 755-770, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30569867
20.
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems.
Eur J Med Chem
; 183: 111674, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31518969