Detalles de la búsqueda
1.
Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.
Bioorg Chem
; 98: 103689, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32171993
2.
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem
; 21(11): 2856-67, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23618709
3.
Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 66(4): 2566-2588, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36749735
4.
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem Lett
; 22(14): 4654-9, 2012 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22726931
5.
Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking.
iScience
; 25(8): 104709, 2022 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35813875
6.
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 62(22): 10108-10123, 2019 11 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31560541
7.
Discovery of novel inhibitors of Aurora kinases with indazole scaffold: In silico fragment-based and knowledge-based drug design.
Eur J Med Chem
; 124: 186-199, 2016 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27573544
8.
Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation.
Oncotarget
; 7(52): 86239-86256, 2016 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27863392
9.
Anchor-based classification and type-C inhibitors for tyrosine kinases.
Sci Rep
; 5: 10938, 2015 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-26077136
10.
Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.
Sci Rep
; 5: 11702, 2015 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26118648
11.
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
J Med Chem
; 58(19): 7807-19, 2015 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26348881
12.
Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.
Eur J Med Chem
; 100: 151-61, 2015 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26081023
13.
Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.
ChemMedChem
; 9(5): 953-61, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24665000
14.
Ligand efficiency based approach for efficient virtual screening of compound libraries.
Eur J Med Chem
; 83: 226-35, 2014 Aug 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24960626
15.
Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer.
PLoS One
; 9(1): e83160, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24416160
16.
3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.
ChemMedChem
; 8(1): 136-48, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23172777
17.
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.
J Med Chem
; 56(13): 5247-60, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23808327
18.
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.
J Med Chem
; 56(10): 3889-903, 2013 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-23611691
19.
A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.
Anticancer Res
; 32(1): 147-51, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22213300
20.
Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor.
ChemMedChem
; 5(2): 255-67, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20039358