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1.
Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates.
Pharm Res
; 38(3): 415-428, 2021 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-33686560
2.
Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation.
Invest New Drugs
; 38(6): 1796-1806, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32451663
3.
Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy.
Drug Metab Dispos
; 47(6): 648-656, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940629
4.
Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice.
J Pharmacol Exp Ther
; 367(3): 414-424, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30228112
5.
Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment.
J Pharmacokinet Pharmacodyn
; 43(1): 29-43, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26578442
6.
Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment.
J Pharmacokinet Pharmacodyn
; 43(1): 13-27, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26563503
7.
Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients.
Invest New Drugs
; 32(5): 985-94, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24875134
8.
Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics.
J Biopharm Stat
; 24(3): 471-92, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-24697342
9.
Bioavailability of three novel oral, sustained-release pellets, relative to an immediate-release tablet containing 500 mg flucytosine: A randomized, open-label, crossover study in healthy volunteers.
Clin Transl Sci
; 17(3): e13756, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38488418
10.
A physiologically based pharmacokinetic model for strontium exposure in rat.
Pharm Res
; 30(6): 1536-52, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23543304
11.
Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.
Pharm Res
; 30(10): 2640-53, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23737346
12.
Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials.
Drug Discov Today
; 28(7): 103605, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37146963
13.
How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example.
Clin Pharmacol Ther
; 113(2): 310-320, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35355254
14.
Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models.
Biometrics
; 68(1): 146-55, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22049987
15.
Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia.
Cancer Res Commun
; 2(11): 1532-1544, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36970053
16.
Impact of Hepatic CYP3A4 Ontogeny Functions on Drug-Drug Interaction Risk in Pediatric Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study.
Clin Pharmacol Ther
; 109(6): 1618-1630, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33283268
17.
Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions.
Eur J Pharm Sci
; 165: 105932, 2021 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34260894
18.
Modeling restoration of gefitinib efficacy by co-administration of MET inhibitors in an EGFR inhibitor-resistant NSCLC xenograft model: A tumor-in-host DEB-based approach.
CPT Pharmacometrics Syst Pharmacol
; 10(11): 1396-1411, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34708556
19.
Impact of interleukin-6 on drug transporters and permeability in the hCMEC/D3 blood-brain barrier model.
Fundam Clin Pharmacol
; 35(2): 397-409, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32757312
20.
Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Clin Pharmacol Ther
; 109(3): 605-618, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32686076