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1.
A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer.
Prostate
; 84(6): 605-619, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38375594
2.
Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer.
J Enzyme Inhib Med Chem
; 39(1): 2318645, 2024 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38465731
3.
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.
Toxicol Appl Pharmacol
; 480: 116745, 2023 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37931757
4.
Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Bioorg Chem
; 110: 104813, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33774493
5.
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
Bioorg Chem
; 95: 103135, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31923631
6.
A highly HDAC6-selective inhibitor acts as a fluorescent probe.
Org Biomol Chem
; 16(42): 7820-7832, 2018 10 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-30168823
7.
J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice.
Eur J Pharm Sci
; 194: 106696, 2024 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38199443
8.
Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-ß-Induced Idiopathic Pulmonary Fibrosis.
J Med Chem
; 66(15): 10528-10557, 2023 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37463500
9.
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Bioorg Med Chem
; 19(21): 6316-28, 2011 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21958737
10.
Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-ß-carboline analogs as potential antitumor agents.
Mar Drugs
; 9(2): 256-277, 2011 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21566798
11.
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
Bioorg Med Chem
; 18(2): 597-604, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20056549
12.
Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.
Bioorg Med Chem
; 18(13): 4674-86, 2010 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20570526
13.
Cytotoxicity and reversal of multidrug resistance by tryptanthrin-derived indoloquinazolines.
Acta Pharmacol Sin
; 31(2): 259-64, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20139909
14.
Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.
J Med Chem
; 63(15): 8485-8494, 2020 08 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32663396
15.
An improved screening model to identify inhibitors targeting zinc-enhanced amyloid aggregation.
Anal Chem
; 81(16): 6944-51, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19621898
16.
Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through c-jun NH2-terminal kinase-mediated apoptosis.
Anticancer Drugs
; 20(5): 382-8, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19318911
17.
High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma.
Biochem Pharmacol
; 163: 458-471, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30885763
18.
Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.
ACS Med Chem Lett
; 10(1): 22-26, 2019 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30655941
19.
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
J Med Chem
; 62(2): 857-874, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30525585
20.
Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.
J Med Chem
; 51(6): 1740-6, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18318465