Detalles de la búsqueda
1.
Development of a degrader against oncogenic fusion protein FGFR3-TACC3.
Bioorg Med Chem Lett
; 60: 128584, 2022 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35085722
2.
Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.
Bioorg Med Chem
; 54: 116553, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34953340
3.
New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-ß-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.
Bioorg Med Chem
; 66: 116830, 2022 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35594648
4.
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
J Biol Chem
; 293(18): 6776-6790, 2018 05 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29545311
5.
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
Chem Pharm Bull (Tokyo)
; 67(3): 203-209, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30369550
6.
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).
J Biol Chem
; 292(11): 4556-4570, 2017 03 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-28154167
7.
SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.
Cancer Sci
; 108(5): 1032-1041, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28192613
8.
Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.
Cancer Sci
; 108(8): 1657-1666, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28556300
9.
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
Biochem Biophys Res Commun
; 484(3): 605-611, 2017 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28153726
10.
2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Bioorg Med Chem
; 25(14): 3658-3670, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533114
11.
Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Bioorg Med Chem
; 25(7): 2133-2147, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284870
12.
Synthesis of SNIPERs against BCR-ABL with kinase inhibitors and a method to evaluate their growth inhibitory activity derived from BCR-ABL degradation.
Methods Enzymol
; 681: 41-60, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36764763
13.
Second-Generation AUTACs for Targeted Autophagic Degradation.
J Med Chem
; 66(17): 12342-12372, 2023 09 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37589438
14.
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
J Med Chem
; 64(17): 12582-12602, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34437804
15.
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
J Med Chem
; 63(3): 1084-1104, 2020 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31895562
16.
Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Sci Adv
; 5(5): eaav3660, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31131319
17.
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
Sci Rep
; 8(1): 13549, 2018 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30202081
18.
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.
J Med Chem
; 61(2): 543-575, 2018 01 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28594553
19.
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.
ACS Med Chem Lett
; 8(10): 1042-1047, 2017 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29057048
20.
Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
J Med Chem
; 49(13): 3809-25, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789738