Detalles de la búsqueda
1.
Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer's disease.
Bioorg Med Chem Lett
; 99: 129622, 2024 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38244940
2.
Design, synthesis, and bioactivity evaluation of novel 1-(4-(benzylsulfonyl)-2-nitrophenyl) derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury.
Bioorg Med Chem Lett
; 80: 129097, 2023 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36462751
3.
Synthesis and SAR study of novel diimide skeleton compounds with the anti-inflammatory activities in vitro and in vivo.
Bioorg Med Chem
; 90: 117353, 2023 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37257256
4.
Design and synthesis optimization of novel diimide indoles derivatives for ameliorating acute lung injury through modulation of NF-κB signaling pathway.
Bioorg Chem
; 136: 106557, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121106
5.
SAR study of bisamides as cyclophilin a inhibitors for the development of host-targeting therapy for hepatitis C virus infection.
Bioorg Med Chem
; 28(19): 115679, 2020 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32912430
6.
Berberine bioisostere Q8 compound stimulates osteoblast differentiation and function in vitro.
Pharmacol Res
; 119: 463-475, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28286134
7.
Design and synthesis of novel androgen receptor antagonists via molecular modeling.
Bioorg Med Chem
; 24(4): 789-801, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26780832
8.
The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3.
Bioorg Med Chem
; 24(21): 5036-5046, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27555284
9.
Computer-aided discovery of aminopyridines as novel JAK2 inhibitors.
Bioorg Med Chem
; 23(5): 985-95, 2015 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25650310
10.
Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis.
Eur J Med Chem
; 272: 116487, 2024 Jun 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-38759452
11.
Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice.
Eur J Med Chem
; 268: 116252, 2024 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38422703
12.
6,7-Dimethoxy-3-(3-methoxyphenyl)isoquinolin-1-amine induces mitotic arrest and apoptotic cell death through the activation of spindle assembly checkpoint in human cervical cancer cells.
Carcinogenesis
; 34(8): 1852-60, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23615402
13.
Structure-based virtual screening and identification of a novel androgen receptor antagonist.
J Biol Chem
; 287(36): 30769-80, 2012 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-22798067
14.
Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.
J Biol Chem
; 287(26): 21628-39, 2012 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22549789
15.
Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis.
Hepatology
; 55(5): 1379-88, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22183856
16.
Discovery of the Diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway.
J Med Chem
; 66(17): 12304-12323, 2023 09 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37643372
17.
Design, synthesis, and bioactivity evaluation of novel amide/sulfonamide derivatives as potential anti-inflammatory agents against acute lung injury and ulcerative colitis.
Eur J Med Chem
; 259: 115706, 2023 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37572538
18.
Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen.
J Med Chem
; 66(10): 6938-6958, 2023 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37130331
19.
Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis.
Eur J Med Chem
; 249: 115144, 2023 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36708679
20.
Structure-based discovery of pyrazolamides as novel ERRγ inverse agonists.
Eur J Med Chem
; 250: 115174, 2023 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36805944