Detalles de la búsqueda
1.
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids.
Cell Mol Life Sci
; 81(1): 36, 2024 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38214768
2.
Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides.
Proc Natl Acad Sci U S A
; 118(2)2021 01 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33372146
3.
Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity.
J Neurosci
; 41(10): 2119-2134, 2021 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33526476
4.
Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor.
J Neurosci
; 40(31): 5922-5936, 2020 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32611707
5.
Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives.
J Neurosci
; 36(7): 2161-75, 2016 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-26888927
6.
5ß-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia.
J Steroid Biochem Mol Biol
; 239: 106464, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38246201
7.
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Pharmacol Rep
; 75(1): 177-188, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36422805
8.
Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior.
ACS Chem Neurosci
; 14(10): 1870-1883, 2023 05 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37126803
9.
Identification of N-methyl-D-aspartate receptor antagonists using the rat postnatal mixed cortical and hippocampal neurons.
Eur J Pharmacol
; 927: 175056, 2022 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636520
10.
Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.
Br J Pharmacol
; 179(15): 3970-3990, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35318645
11.
The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains.
Pharmaceuticals (Basel)
; 15(1)2021 Dec 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35056106
12.
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms.
Br J Pharmacol
; 178(19): 3888-3904, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33988248
13.
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Biomolecules
; 11(7)2021 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-34356650
14.
Synthetic structural modifications of neurosteroid pregnanolone sulfate: Assessment of neuroprotective effects in vivo.
Eur J Pharmacol
; 881: 173187, 2020 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32446713
15.
Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice.
Diabetes
; 69(3): 300-312, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31806624
16.
Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons.
Steroids
; 74(2): 256-63, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19071149
17.
Screening of novel 3α5ß-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.
J Steroid Biochem Mol Biol
; 189: 195-203, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30872014
18.
Pregn-5-en-3ß-ol and androst-5-en-3ß-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability.
Steroids
; 147: 4-9, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30296546
19.
Positive Modulators of the N-Methyl-d-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters.
J Med Chem
; 61(10): 4505-4516, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29708744
20.
Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor.
Org Lett
; 20(4): 946-949, 2018 02 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29364682