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1.
Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
J Biol Chem
; 281(45): 34056-63, 2006 Nov 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973622
2.
The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells.
Biochem Biophys Res Commun
; 343(4): 1002-8, 2006 May 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-16579968
3.
Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger.
Mol Pharmacol
; 68(6): 1803-9, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16155211
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