Detalles de la búsqueda
1.
Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.
Drug Metab Dispos
; 51(10): 1284-1294, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37349116
2.
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models.
Haematologica
; 106(4): 1034-1046, 2021 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32414851
3.
Bioactivation of α,ß-Unsaturated Carboxylic Acids Through Acyl Glucuronidation.
Drug Metab Dispos
; 48(9): 819-829, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32616543
4.
Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs.
Toxicol Pathol
; 48(3): 465-480, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32124659
5.
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.
Bioorg Med Chem Lett
; 28(1): 15-23, 2018 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29169673
6.
Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.
Biopharm Drug Dispos
; 39(9): 420-430, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30335192
7.
Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions.
Mol Pharm
; 14(5): 1754-1759, 2017 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28345929
8.
Absorption, metabolism and excretion of cobimetinib, an oral MEK inhibitor, in rats and dogs.
Xenobiotica
; 47(1): 50-65, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055783
9.
Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.
Drug Metab Dispos
; 44(1): 28-39, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26451002
10.
Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.
Drug Metab Dispos
; 43(12): 1929-33, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26438627
11.
Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.
Drug Metab Dispos
; 43(6): 864-9, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25813936
12.
The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199.
Drug Metab Dispos
; 42(2): 207-12, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24212376
13.
Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.
Mol Pharm
; 11(11): 4199-207, 2014 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25243894
14.
Assessment of the hepatic CYP reductase null mouse model and its potential application in drug discovery.
Mol Pharm
; 11(3): 1062-8, 2014 Mar 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-24450768
15.
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg Med Chem Lett
; 24(19): 4714-4723, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25193232
16.
Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts.
Breast Cancer Res Treat
; 139(1): 61-9, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23605084
17.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol
; 266(1): 86-94, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142475
18.
Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.
Drug Metab Dispos
; 40(5): 919-27, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22315332
19.
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
ACS Med Chem Lett
; 13(1): 84-91, 2022 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-35059127
20.
Preclinical assessment of novel BRAF inhibitors: integrating pharmacokinetic-pharmacodynamic modelling in the drug discovery process.
Xenobiotica
; 41(12): 1076-87, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-21864203