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1.
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg Med Chem Lett
; 22(12): 4089-93, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22595176
2.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg Med Chem Lett
; 22(15): 4967-74, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22765895
3.
Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Chem Res Toxicol
; 23(11): 1743-52, 2010 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20825217
4.
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg Med Chem Lett
; 19(22): 6307-12, 2009 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19819693
5.
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
J Med Chem
; 51(6): 1668-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324759
6.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
J Med Chem
; 51(6): 1649-67, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18324761
7.
Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase.
J Med Chem
; 51(10): 2879-82, 2008 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-18426196
8.
Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2H)-ones as potent and selective inhibitors of KDR: synthesis, SAR, and pharmacokinetic properties.
Bioorg Med Chem Lett
; 18(14): 4054-8, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18573658
9.
In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Mol Cancer Ther
; 15(7): 1568-79, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27196782
10.
Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J Med Chem
; 59(6): 2328-42, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26812066
11.
Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors.
J Med Chem
; 58(5): 2417-30, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25699405
12.
VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia.
J Med Chem
; 55(2): 725-34, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22221201
13.
The discovery and optimization of a novel class of potent, selective, and orally bioavailable anaplastic lymphoma kinase (ALK) inhibitors with potential utility for the treatment of cancer.
J Med Chem
; 55(14): 6523-40, 2012 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22734674
14.
Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia.
J Med Chem
; 54(20): 7184-92, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21970471
15.
Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors.
J Med Chem
; 58(9): 4087, 2015 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25901648
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