Detalles de la búsqueda
1.
Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24-hydroxylase inhibitor soticlestat in healthy volunteers.
Br J Clin Pharmacol
; 90(2): 516-527, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37771051
2.
Determination of Acyl-, O-, and N-Glucuronide Using Chemical Derivatization Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry.
Drug Metab Dispos
; 50(5): 716-724, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35241454
3.
Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors.
Drug Metab Dispos
; 50(7): 989-997, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35504658
4.
Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model.
Drug Metab Dispos
; 50(7): 980-988, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35545257
5.
Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate.
Drug Metab Dispos
; 48(11): 1239-1245, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32843329
6.
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Drug Metab Dispos
; 48(3): 217-229, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31911485
7.
Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors.
Invest New Drugs
; 37(4): 666-673, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30397836
8.
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics.
Drug Metab Dispos
; 46(11): 1692-1702, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076203
9.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29487142
10.
Carbon-carbon bond cleavage and formation reactions in drug metabolism and the role of metabolic enzymes.
Drug Metab Rev
; 47(4): 534-57, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26390887
11.
Clinical and Nonclinical Disposition and In Vitro Drug-Drug Interaction Potential of Felcisetrag, a Highly Selective and Potent 5-HT4 Receptor Agonist.
Eur J Drug Metab Pharmacokinet
; 47(3): 371-386, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35157234
12.
Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist).
AAPS J
; 24(6): 99, 2022 09 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-36123502
13.
Analytical strategies for assessment of human metabolites in preclinical safety testing.
Anal Chem
; 83(13): 5028-36, 2011 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21506522
14.
Precision and accuracy in the quantitative analysis of biological samples by accelerator mass spectrometry: application in microdose absolute bioavailability studies.
Anal Chem
; 83(14): 5607-16, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21627104
15.
Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.
Drug Metab Dispos
; 39(1): 30-8, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20926621
16.
Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor.
Drug Metab Dispos
; 39(3): 510-21, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21123164
17.
Quantitation of parent drug and its unstable metabolites by in situ coulometric oxidation and liquid chromatography-tandem mass spectrometry.
Anal Chem
; 82(24): 10251-7, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21105697
18.
Identification of two novel metabolites of SCH 486757, a nociceptin/orphanin FQ peptide receptor agonist, in humans.
Drug Metab Dispos
; 38(11): 2067-74, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20671096
19.
Determination of exposure multiples of human metabolites for MIST assessment in preclinical safety species without using reference standards or radiolabeled compounds.
Chem Res Toxicol
; 23(12): 1871-3, 2010 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21121646
20.
Response normalized liquid chromatography nanospray ionization mass spectrometry.
J Am Soc Mass Spectrom
; 18(10): 1891-9, 2007 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17766144