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1.
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats.
Toxicol Pathol
; 51(1-2): 15-26, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37078689
2.
Effects of LRRK2 Inhibitors in Nonhuman Primates.
Toxicol Pathol
; 51(5): 232-245, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37916535
3.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
J Pharmacol Exp Ther
; 377(1): 11-19, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509901
4.
Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.
Bioorg Med Chem
; 22(19): 5392-409, 2014 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25155913
5.
Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor.
J Toxicol Pathol
; 27(1): 31-42, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24791065
6.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37861679
7.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34967623
8.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36475697
9.
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.
Bioorg Med Chem Lett
; 21(11): 3399-403, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21524576
10.
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
RSC Med Chem
; 12(7): 1164-1173, 2021 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-34355182
11.
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
Toxicol Sci
; 82(1): 341-58, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15319485
12.
Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers.
Toxicol Sci
; 137(2): 278-91, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24189134
13.
Differential cytotoxicity responses by dog and rat hepatocytes to phospholipogenic treatments.
J Toxicol
; 2013: 956404, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23577025
14.
Phospholipogenic pharmaceuticals are associated with a higher incidence of histological findings than nonphospholipogenic pharmaceuticals in preclinical toxicology studies.
J Toxicol
; 2012: 308594, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22745636
15.
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.
J Med Chem
; 55(15): 6916-33, 2012 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22779424
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