Detalles de la búsqueda
1.
The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites.
J Neurochem
; 2023 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38131125
2.
A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.
J Biol Chem
; 293(29): 11574-11588, 2018 07 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29871924
3.
A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration.
Biochim Biophys Acta Mol Basis Dis
; 1864(7): 2420-2429, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29684583
4.
Modulation of NMDA receptor function as a treatment for schizophrenia.
Bioorg Med Chem Lett
; 23(18): 5034-44, 2013 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23916256
5.
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
Bioorg Med Chem Lett
; 23(5): 1257-61, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23380375
6.
Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.
ACS Chem Neurosci
; 14(15): 2634-2647, 2023 08 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37466545
7.
Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals.
Front Chem
; 10: 948553, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36353143
8.
The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration.
PLoS One
; 17(10): e0269437, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36227868
9.
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Bioorg Med Chem Lett
; 21(1): 58-61, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21146988
10.
Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.
Biomolecules
; 11(6)2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34200954
11.
Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction: Potential Novel Therapeutics for Macular Degeneration, Transthyretin Amyloidosis, and Their Common Age-Related Comorbidities.
J Med Chem
; 64(13): 9010-9041, 2021 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34138572
12.
Synthesis of 2-aminobenzoxazoles using tetramethyl orthocarbonate or 1,1-dichlorodiphenoxymethane.
J Org Chem
; 75(22): 7942-5, 2010 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-20973518
13.
Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.
J Med Chem
; 63(19): 11054-11084, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32878437
14.
Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.
ACS Chem Neurosci
; 11(9): 1250-1258, 2020 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32191428
15.
Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.
PLoS One
; 14(10): e0224094, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31648246
16.
Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.
J Med Chem
; 62(11): 5470-5500, 2019 06 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31079449
17.
Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain.
J Med Chem
; 61(7): 2652-2679, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28876062
18.
Glycine transporter-1 inhibitors: a patent review (2011-2016).
Expert Opin Ther Pat
; 28(3): 197-210, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29338548
19.
Inhibitors of Glycine Transporter-1: Potential Therapeutics for the Treatment of CNS Disorders.
Curr Top Med Chem
; 16(29): 3404-3437, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27048272
20.
Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1.
J Med Chem
; 59(18): 8473-94, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27559615