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1.
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Proc Natl Acad Sci U S A
; 116(4): 1414-1419, 2019 01 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-30617067
2.
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.
Proc Natl Acad Sci U S A
; 114(45): E9712-E9721, 2017 11 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29078351
3.
African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
BMJ Glob Health
; 9(3)2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38485142
4.
An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.
Biochem Pharmacol
; 216: 115758, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37604290
5.
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors.
Front Pharmacol
; 14: 1328950, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38273820
6.
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform.
Front Pharmacol
; 14: 1331224, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38273832
7.
In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus.
Toxicon X
; 14: 100118, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35321116
8.
Small Molecule Drug Discovery for Neglected Tropical Snakebite.
Trends Pharmacol Sci
; 42(5): 340-353, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33773806
9.
The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming.
Toxins (Basel)
; 13(7)2021 06 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34209691
10.
Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis.
ACS Med Chem Lett
; 12(9): 1421-1426, 2021 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34527179
11.
Development of a High-Throughput Cytometric Screen to Identify Anti- Wolbachia Compounds: The Power of Public-Private Partnership.
SLAS Discov
; 24(5): 537-547, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30958712
12.
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Nat Commun
; 10(1): 11, 2019 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30602718
13.
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.
Sci Transl Med
; 11(483)2019 03 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30867321
14.
Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sci Rep
; 8: 46934, 2018 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29308790
15.
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Sci Rep
; 8(1): 1384, 2018 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29348597
16.
Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.
Sci Adv
; 3(9): eaao1551, 2017 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28959730
17.
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Sci Rep
; 7(1): 210, 2017 03 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-28303006
18.
Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sci Rep
; 6: 23458, 2016 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-26996237
19.
Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.
J Biomol Screen
; 20(1): 64-9, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25278497
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