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1.
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations.
Proc Natl Acad Sci U S A
; 105(5): 1466-71, 2008 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-18230722
2.
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
J Biol Chem
; 284(50): 35092-100, 2009 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-19812032
3.
Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.
Nucleic Acids Res
; 36(15): 5083-92, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18676450
4.
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
Nat Struct Mol Biol
; 11(5): 469-74, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15107837
5.
Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.
J Mol Biol
; 365(1): 77-89, 2007 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17056061
6.
Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.
Structure
; 12(4): 657-67, 2004 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15062088
7.
Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
J Med Chem
; 48(6): 1974-83, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771441
8.
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
J Med Chem
; 48(24): 7582-91, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16302798
9.
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
J Med Chem
; 47(10): 2550-60, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115397
10.
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
J Med Chem
; 54(8): 2727-37, 2011 Apr 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21446702
11.
Structural basis of HIV-1 resistance to AZT by excision.
Nat Struct Mol Biol
; 17(10): 1202-9, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20852643
12.
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure
; 17(12): 1625-1635, 2009 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20004166
13.
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
ACS Chem Biol
; 1(11): 702-12, 2006 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17184135
14.
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell
; 122(4): 541-52, 2005 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-16122422
15.
Trapping HIV-1 reverse transcriptase before and after translocation on DNA.
J Biol Chem
; 278(18): 16280-8, 2003 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12554739
16.
Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.
EMBO J
; 21(23): 6614-24, 2002 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12456667
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