Detalles de la búsqueda
1.
An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS-708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog.
Bioorg Med Chem Lett
; 30(3): 126856, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31870650
2.
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
J Pharmacol Exp Ther
; 358(1): 125-37, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27189974
3.
Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.
Bioorg Med Chem Lett
; 23(13): 3814-7, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23726344
4.
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3ß (GSK-3ß) Inhibitors.
J Med Chem
; 66(6): 4231-4252, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36950863
5.
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
J Med Chem
; 66(11): 7534-7552, 2023 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37235865
6.
Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one.
Bioorg Med Chem Lett
; 20(10): 3182-5, 2010 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20399649
7.
A question of value: a qualitative study of vocational dental practitioners' views on oral healthcare systems and their future careers.
Prim Dent Care
; 16(1): 29-37, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19126350
8.
The emerging dental workforce: short-term expectations of, and influences on dental students graduating from a London dental school in 2005.
Prim Dent Care
; 15(3): 93-101, 2008 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-18755059
9.
Dentistry - a professional contained career in healthcare. A qualitative study of Vocational Dental Practitioners' professional expectations.
BMC Oral Health
; 7: 16, 2007 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-18005452
10.
Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as α7 Nicotinic Receptor Agonists.
ACS Med Chem Lett
; 8(1): 133-137, 2017 Jan 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28105289
11.
BMS-933043, a Selective α7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.
ACS Med Chem Lett
; 8(3): 366-371, 2017 Mar 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28337332
12.
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
J Med Chem
; 59(3): 1041-51, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26751161
13.
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.
J Med Chem
; 59(24): 11171-11181, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27958732
14.
Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.
J Med Chem
; 48(18): 5639-43, 2005 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-16134929
15.
Neurochemical, pharmacokinetic, and behavioral effects of the novel selective serotonin reuptake inhibitor BMS-505130.
Pharmacol Biochem Behav
; 80(3): 521-8, 2005 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15740795
16.
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
J Med Chem
; 47(7): 1609-12, 2004 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-15027851
17.
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.
ACS Med Chem Lett
; 5(7): 760-5, 2014 Jul 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-25050161
18.
Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.
ACS Med Chem Lett
; 3(3): 222-6, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900458
19.
Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.
J Med Chem
; 51(19): 5897-900, 2008 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-18763755
20.
Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors.
Bioorg Med Chem Lett
; 17(15): 4284-9, 2007 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17540562