Detalles de la búsqueda
1.
GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
Bioorg Med Chem Lett
; 23(23): 6463-6, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24140446
2.
Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.
Invest New Drugs
; 30(3): 936-49, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21360050
3.
Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt).
J Med Chem
; 64(9): 5470-5484, 2021 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33852312
4.
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.
J Med Chem
; 51(7): 2302-6, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18314943
5.
Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.
J Chem Theory Comput
; 14(5): 2721-2732, 2018 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29474075
6.
Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-ß receptor type I inhibitor.
Oncotarget
; 9(6): 6659-6677, 2018 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29467918
7.
Synthesis and Pharmacological Characterization of C4ß-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.
J Med Chem
; 61(6): 2303-2328, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29350927
8.
Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.
J Med Chem
; 49(6): 2138-42, 2006 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16539403
9.
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J Med Chem
; 58(18): 7526-48, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26313429
10.
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
J Med Chem
; 58(10): 4165-79, 2015 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25965804
11.
Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.
J Med Chem
; 58(4): 1776-94, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25602126
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