Detalles de la búsqueda
1.
Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.
Molecules
; 27(21)2022 Nov 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364360
2.
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators.
Molecules
; 27(21)2022 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364467
3.
Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1.
Bioorg Chem
; 99: 103825, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32334191
4.
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.
Bioorg Med Chem
; 25(20): 5779-5789, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28951095
5.
SYNTHESIS OF IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS POSSIBLE BIOLOGICALLY ACTIVE AGENTS.
Acta Pol Pharm
; 73(4): 913-929, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29648717
6.
Association of human leukocyte antigen (HLA) footprints with the comorbidity of latent autoimmune diabetes in adults (LADA) and hepatitis C virus (HCV) infection: A multicenter cross-sectional study.
Diabetes Metab Syndr
; 18(1): 102939, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38181721
7.
Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs.
Eur J Med Chem
; 246: 114939, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36442370
8.
Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility.
Acta Pharm Sin B
; 13(12): 4906-4917, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-38045058
9.
Identification of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.
Eur J Med Chem
; 247: 115045, 2023 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36577216
10.
Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation.
Eur J Med Chem
; 246: 114957, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36446205
11.
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
Bioorg Med Chem
; 20(23): 6795-802, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23098609
12.
Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation).
Antivir Chem Chemother
; 30: 20402066221129979, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36305032
13.
Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase.
Eur J Med Chem
; 238: 114512, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35679690
14.
Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors.
Eur J Med Chem
; 240: 114563, 2022 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35780636
15.
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
Bioorg Med Chem
; 19(23): 7093-9, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22037050
16.
Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: synthesis, ¹H/¹³C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations.
Molecules
; 16(7): 6023-40, 2011 Jul 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-21772234
17.
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.
Biomedicines
; 9(4)2021 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33920487
18.
The unsaturated acyclic nucleoside analogues bearing a sterically constrained (Z)-4'-benzamido-2'-butenyl moiety: Synthesis, X-ray crystal structure study, cytostatic and antiviral activity evaluations.
Bioorg Med Chem
; 18(17): 6249-57, 2010 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20696582
19.
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.
Bioorg Med Chem
; 18(13): 4601-5, 2010 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20570527
20.
Clinical characteristics of older and younger patients infected with SARS-CoV-2.
Aging (Albany NY)
; 12(12): 11296-11305, 2020 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32575073