Detalles de la búsqueda
1.
Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity.
Int J Toxicol
; 42(1): 19-36, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36523256
2.
The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay.
Toxicol Appl Pharmacol
; 387: 114774, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31783037
3.
Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human.
J Toxicol Environ Health A
; 83(19-20): 631-648, 2020 10 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32757748
4.
An evaluation of the USEPA Proposed Approaches for applying a biologically based dose-response model in a risk assessment for perchlorate in drinking water.
Regul Toxicol Pharmacol
; 103: 237-252, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30707931
5.
An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis.
Toxicol Appl Pharmacol
; 355: 112-126, 2018 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29782964
6.
Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts.
Crit Rev Toxicol
; 47(7): 564-580, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28675057
7.
Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.
Mutagenesis
; 31(3): 333-40, 2016 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26846943
8.
Pathway Based Toxicology and Fit-for-Purpose Assays.
Adv Exp Med Biol
; 856: 205-230, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27671724
9.
An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies.
Toxicol In Vitro
; 82: 105365, 2022 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-35470028
10.
Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation.
Front Toxicol
; 4: 894569, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35573278
11.
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.
Front Pharmacol
; 13: 980747, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36278238
12.
Time-dependent genomic response in primary human uroepithelial cells exposed to arsenite for up to 60 days.
Toxicology
; 461: 152893, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34425169
13.
Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates.
Toxicol In Vitro
; 66: 104855, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32278033
14.
Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods.
Toxicol In Vitro
; 64: 104463, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-31628012
15.
In utero exposure to chloroquine alters sexual development in the male fetal rat.
Toxicol Appl Pharmacol
; 237(3): 366-74, 2009 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19393257
16.
Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats.
Toxicology
; 255(1-2): 80-90, 2009 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19010379
17.
Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.
Chem Biol Interact
; 301: 112-127, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30763550
18.
Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures.
Toxicol In Vitro
; 58: 1-12, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-30807807
19.
Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).
ALTEX
; 36(4): 523-534, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31664457
20.
Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system.
Toxicol In Vitro
; 54: 41-57, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-30218698