Detalles de la búsqueda
1.
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models.
Arch Toxicol
; 97(2): 523-545, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36576512
2.
A Modified Arrhenius Approach to Thermodynamically Study Regioselectivity in Cytochrome P450-Catalyzed Substrate Conversion.
Chembiochem
; 21(10): 1461-1472, 2020 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31919943
3.
Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Appl Microbiol Biotechnol
; 103(9): 3597-3614, 2019 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-30810776
4.
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.
Chem Res Toxicol
; 31(2): 116-126, 2018 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29281794
5.
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Appl Microbiol Biotechnol
; 102(21): 9231-9242, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30136203
6.
Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
Br J Clin Pharmacol
; 83(3): 572-583, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27718269
7.
Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.
Proteins
; 84(3): 383-96, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26757175
8.
Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.
Chem Res Toxicol
; 29(12): 2136-2144, 2016 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27989146
9.
Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.
Anal Bioanal Chem
; 408(5): 1425-43, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26753974
10.
Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP).
Chem Res Toxicol
; 28(4): 711-21, 2015 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25706813
11.
Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme.
Appl Microbiol Biotechnol
; 99(11): 4713-21, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25511824
12.
Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
Chem Res Toxicol
; 27(12): 2071-81, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25372302
13.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Chem Res Toxicol
; 27(4): 576-86, 2014 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24552538
14.
Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.
Bioorg Med Chem
; 22(20): 5613-20, 2014 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24999003
15.
A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.
Arch Toxicol
; 88(5): 1083-95, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24599296
16.
Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
Drug Metab Dispos
; 41(3): 651-8, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23297297
17.
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Chem Res Toxicol
; 26(11): 1632-41, 2013 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24083800
18.
AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver.
Arch Toxicol
; 87(1): 155-65, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22914986
19.
Exposure to cis- and trans-regioisomers of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-glutathione result in quantitatively and qualitatively different cellular effects in RPTEC/TERT1 cells.
Toxicol Lett
; 383: 75-88, 2023 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37353095
20.
A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
Chembiochem
; 13(4): 520-3, 2012 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22275147