Detalles de la búsqueda
1.
Design and structure-activity relationships of 2-alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
J Med Chem
; 46(9): 1769-72, 2003 Apr 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12699396
2.
Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
J Med Chem
; 46(11): 2023-6, 2003 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-12747774
3.
Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
J Med Chem
; 47(5): 1259-71, 2004 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-14971906
4.
3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
J Med Chem
; 47(14): 3483-6, 2004 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15214774
5.
6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain.
Bioorg Med Chem Lett
; 13(11): 1927-30, 2003 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12749900
6.
Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
Bioorg Med Chem Lett
; 13(19): 3317-22, 2003 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12951117
7.
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(3): 399-402, 2002 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11814806
8.
Synthesis and initial structure-activity relationships of a novel series of imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(16): 2179-83, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127532
9.
Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.
Bioorg Med Chem Lett
; 13(11): 1931-4, 2003 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12749901
10.
A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(23): 3491-5, 2002 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-12419391
11.
A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(3): 403-6, 2002 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11814807
12.
Design, synthesis and structure-activity relationships of novel imidazolo[1,2-a]pyrimid-5-ones as potent GnRH receptor antagonists.
Bioorg Med Chem Lett
; 12(16): 2185-7, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127533
13.
Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
Bioorg Med Chem Lett
; 14(19): 4967-73, 2004 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-15341961
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