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1.
Discovery, design, and synthesis of indole-based EZH2 inhibitors.
Bioorg Med Chem Lett
; 25(17): 3644-9, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26189078
2.
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.
Bioorg Med Chem Lett
; 17(24): 6691-6, 2007 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17976986
3.
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J Med Chem
; 59(21): 9928-9941, 2016 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27739677
4.
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.
Chem Biol
; 21(11): 1463-75, 2014 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25457180
5.
Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
J Med Chem
; 57(4): 1170-87, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24432909
6.
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.
J Med Chem
; 55(22): 9831-7, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23095041
7.
Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
Bioorg Med Chem
; 15(1): 142-59, 2007 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17070062
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