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1.
A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.
PLoS Comput Biol
; 13(2): e1005280, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28151932
2.
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.
Arch Toxicol
; 91(2): 865-883, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-27161439
3.
A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy.
Antimicrob Agents Chemother
; 60(10): 6134-45, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27480867
4.
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Arch Toxicol
; 92(1): 553-555, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28852801
5.
Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species.
CPT Pharmacometrics Syst Pharmacol
; 12(3): 311-319, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36715173
6.
A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Clin Pharmacol Ther
; 110(5): 1293-1301, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34462909
7.
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells.
SLAS Discov
; 25(3): 265-276, 2020 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-31658853
8.
Network integration and modelling of dynamic drug responses at multi-omics levels.
Commun Biol
; 3(1): 573, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33060801
9.
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients.
Front Physiol
; 10: 1192, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31611804
10.
Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation.
NPJ Syst Biol Appl
; 4: 10, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29507756
11.
Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations.
NPJ Syst Biol Appl
; 4: 28, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30083389
12.
Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.
Toxicol Lett
; 294: 184-192, 2018 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29803840
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