Detalles de la búsqueda
1.
Anorectic effect of COR659 in a rat model of overeating.
Behav Pharmacol
; 34(7): 437-442, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37712580
2.
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Molecules
; 28(13)2023 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37446625
3.
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity.
Molecules
; 28(15)2023 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37570828
4.
Development of tolerance upon repeated administration with the GABAB receptor positive allosteric modulator, COR659, on alcohol drinking in rodents.
Am J Drug Alcohol Abuse
; 48(6): 662-672, 2022 11 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36095322
5.
Lipoic/Capsaicin-Related Amides: Synthesis and Biological Characterization of New TRPV1 Agonists Endowed with Protective Properties against Oxidative Stress.
Int J Mol Sci
; 23(21)2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36362364
6.
Structure optimization of positive allosteric modulators of GABAB receptors led to the unexpected discovery of antagonists/potential negative allosteric modulators.
Bioorg Med Chem Lett
; 30(18): 127443, 2020 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32730942
7.
Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.
Bioorg Med Chem
; 28(11): 115513, 2020 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32340793
8.
Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats.
Alcohol Alcohol
; 55(4): 367-373, 2020 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32441305
9.
Hsp90 inhibitors, part 2: combining ligand-based and structure-based approaches for virtual screening application.
J Chem Inf Model
; 54(3): 970-7, 2014 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24555544
10.
Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist.
Bioorg Med Chem
; 22(17): 4770-83, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25065940
11.
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo.
ACS Chem Neurosci
; 15(5): 955-971, 2024 03 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38372253
12.
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition.
Biomedicines
; 11(6)2023 May 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37371642
13.
Reducing effect of intragastrically administered saikosaponin A on alcohol and sucrose self-administration in rats.
Nat Prod Res
; 37(24): 4256-4260, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36787176
14.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.
J Med Chem
; 66(10): 6994-7015, 2023 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37192374
15.
Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA(B) receptor.
J Pharmacol Exp Ther
; 340(3): 529-38, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22129594
16.
A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury.
Pharmacol Res
; 66(6): 555-63, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23036353
17.
Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.
Alcohol Clin Exp Res
; 36(10): 1748-66, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22486245
18.
In Silico Multi-Target Approach Revealed Potential Lead Compounds as Scaffold for the Synthesis of Chemical Analogues Targeting SARS-CoV-2.
Biology (Basel)
; 11(3)2022 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-35336838
19.
Reducing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on binge-like alcohol drinking in male mice and rats.
Psychopharmacology (Berl)
; 239(1): 201-213, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34812900
20.
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.
RSC Med Chem
; 13(7): 873-883, 2022 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35923722