Detalles de la búsqueda
1.
Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.
Drug Metab Dispos
; 52(7): 582-596, 2024 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38697852
2.
Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.
Mol Pharm
; 20(6): 3020-3032, 2023 06 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37134201
3.
A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.
Anal Chem
; 92(14): 9745-9754, 2020 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551505
4.
Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.
Chem Res Toxicol
; 33(1): 223-238, 2020 01 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-31532188
5.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975793
6.
Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.
J Pharmacol Exp Ther
; 364(3): 390-398, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29326367
7.
Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.
Drug Metab Dispos
; 46(8): 1200-1211, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29739809
8.
Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.
Drug Metab Dispos
; 46(8): 1179-1189, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29880631
9.
In vitro studies with two human organic anion transporters: OAT2 and OAT7.
Xenobiotica
; 48(10): 1037-1049, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-28945155
10.
Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.
J Pharmacol Exp Ther
; 352(3): 519-28, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25563903
11.
Evaluation of 14 PFAS for permeability and organic anion transporter interactions: Implications for renal clearance in humans.
Chemosphere
; 361: 142390, 2024 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-38801906
12.
Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.
Mol Pharmacol
; 84(2): 182-9, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23680637
13.
Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs.
Clin Pharmacol Ther
; 113(5): 1058-1069, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36524426
14.
Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk.
J Pharm Sci
; 112(6): 1715-1723, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36682487
15.
Direct activation of human phospholipase C by its well known inhibitor u73122.
J Biol Chem
; 286(14): 12407-16, 2011 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21266572
16.
Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions.
Clin Pharmacol Ther
; 111(2): 404-415, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34605015
17.
Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study.
Antiviral Res
; 208: 105429, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36208677
18.
Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.
Clin Pharmacol Ther
; 109(3): 646-657, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32961594
19.
Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 1018-1031, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34164937
20.
Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).
Biochem Pharmacol
; 174: 113829, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32001236