Detalles de la búsqueda
1.
2'-substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis.
J Med Chem
; 36(10): 1434-42, 1993 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-8496911
2.
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
J Med Chem
; 44(21): 3347-50, 2001 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11585439
3.
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
J Med Chem
; 44(21): 3351-4, 2001 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11585440
4.
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
J Med Chem
; 44(16): 2636-60, 2001 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11472217
5.
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
J Med Chem
; 41(11): 1749-51, 1998 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-9599226
6.
The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.
J Immunol
; 159(9): 4524-31, 1997 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-9379053
7.
Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.
J Immunol
; 161(10): 5681-6, 1998 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-9820549
8.
Biology of TACE inhibition.
Ann Rheum Dis
; 60 Suppl 3: iii25-32, 2001 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-11890648
9.
Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
Bioorg Med Chem Lett
; 8(7): 837-42, 1998 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-9871551
10.
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Bioorg Med Chem Lett
; 9(9): 1279-84, 1999 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-10340614
11.
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorg Med Chem Lett
; 9(10): 1453-8, 1999 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-10360755
12.
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.
Nature
; 378(6555): 406-9, 1995 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-7477380
13.
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.
Bioorg Med Chem Lett
; 9(7): 919-24, 1999 Apr 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-10230611
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