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1.
Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate.
Biochemistry
; 57(11): 1685-1689, 2018 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29499117
2.
Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
Nature
; 491(7424): 458-462, 2012 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23064226
3.
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 64(16): 12286-12303, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34387469
4.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30973731
5.
Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding.
Neuron
; 33(1): 63-74, 2002 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-11779480
6.
Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins.
SLAS Discov
; 23(9): 951-959, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29852073
7.
Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J Med Chem
; 59(8): 3991-4006, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27031670
8.
Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem Biol
; 11(11): 3093-3105, 2016 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27571355
9.
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J Med Chem
; 59(23): 10738-10749, 2016 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27933945
10.
Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
J Med Chem
; 59(11): 5356-67, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27167608
11.
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
ACS Med Chem Lett
; 6(7): 798-803, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191369
12.
Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.
ACS Med Chem Lett
; 6(1): 25-30, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589925
13.
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
ACS Med Chem Lett
; 6(1): 31-6, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589926
14.
GABARAP: lessons for synaptogenesis.
Neuroscientist
; 9(3): 205-16, 2003 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15065816
15.
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.
ChemMedChem
; 9(4): 823-32, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24616449
16.
Higher throughput calorimetry: opportunities, approaches and challenges.
Curr Opin Struct Biol
; 20(5): 598-605, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20888754
17.
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
J Med Chem
; 53(16): 5942-55, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20718493
18.
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
J Med Chem
; 53(16): 5956-69, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20662534
19.
Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies.
J Biol Chem
; 277(36): 33115-26, 2002 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12065585
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