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1.
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Bioorg Med Chem Lett
; 19(16): 4617-21, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19616948
2.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18217703
3.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17824681
4.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25380412
5.
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 3(4): 332-6, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900473
6.
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 54(1): 289-301, 2011 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-21141896
7.
Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.
J Med Chem
; 52(15): 4820-37, 2009 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-19624135
8.
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
J Med Chem
; 51(18): 5843-55, 2008 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18763751
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