Detalles de la búsqueda
1.
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme.
Purinergic Signal
; 2023 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-37906424
2.
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines.
J Enzyme Inhib Med Chem
; 36(1): 1553-1563, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34251942
3.
Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor.
Bioorg Med Chem
; 22(1): 148-66, 2014 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24332652
4.
N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect.
Eur J Med Chem
; 258: 115570, 2023 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37413883
5.
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A1 adenosine receptor.
Bioorg Med Chem
; 20(2): 996-1007, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22182575
6.
Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles.
Pharmaceutics
; 14(4)2022 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35456622
7.
Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivatives.
Bioorg Med Chem Lett
; 21(9): 2746-51, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21146985
8.
New insights into cytotoxic mechanisms of bozepinib against glioblastoma.
Eur J Pharm Sci
; 162: 105823, 2021 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33781855
9.
Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma.
Nanomedicine (Lond)
; 16(23): 2095-2115, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34523353
10.
Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation.
Bioorg Med Chem Lett
; 20(9): 2733-9, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20378350
11.
Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.
Bioorg Med Chem
; 18(14): 5114-22, 2010 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20579891
12.
Homochiral drugs: a demanding tendency of the pharmaceutical industry.
Curr Med Chem
; 16(16): 2064-74, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19519381
13.
alpha-halogenoacrylic derivatives of antitumor agents.
Mini Rev Med Chem
; 9(1): 81-94, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19149662
14.
Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation.
Bioorg Med Chem Lett
; 19(7): 2022-8, 2009 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19250822
15.
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.
Bioorg Med Chem
; 17(19): 6862-71, 2009 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19736015
16.
Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study.
Lett Drug Des Discov
; 6(4): 298-303, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20161090
17.
Synthesis and Characterization of a Click-Assembled 18-Atom Macrocycle That Displays Selective AXL Kinase Inhibitory Activity.
ACS Omega
; 4(25): 21620-21626, 2019 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31867559
18.
Design, synthesis and anticancer activity against the MCF-7 cell line of benzo-fused 1,4-dihetero seven- and six-membered tethered pyrimidines and purines.
Curr Med Chem
; 15(25): 2614-31, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18855682
19.
Synthesis and biological evaluation of 1-methyl-2-(3',4',5'-trimethoxybenzoyl)-3-aminoindoles as a new class of antimitotic agents and tubulin inhibitors.
J Med Chem
; 51(5): 1464-8, 2008 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18260616
20.
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerization.
Bioorg Med Chem Lett
; 18(18): 5041-5, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18725179