Detalles de la búsqueda
1.
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature
; 504(7480): 437-40, 2013 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-24226772
2.
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg Med Chem Lett
; 21(8): 2394-9, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21414779
3.
2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
J Med Chem
; 50(3): 429-32, 2007 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17266194
4.
Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.
J Med Chem
; 58(11): 4462-82, 2015 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25914941
5.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N â S (nN â σ*S-X) Interaction for Conformational Constraint.
J Med Chem
; 58(24): 9663-79, 2015 Dec 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26551034
6.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.
J Med Chem
; 57(14): 5949-64, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25001129
7.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.
J Med Chem
; 57(7): 3094-116, 2014 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24611879
8.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.
J Med Chem
; 57(2): 309-24, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405172
9.
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
J Med Chem
; 57(2): 325-38, 2014 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405213
10.
Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).
J Med Chem
; 53(11): 4481-7, 2010 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20465278
11.
Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
Chem Biol Drug Des
; 71(1): 36-44, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18069989
12.
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
J Med Chem
; 51(24): 7953-67, 2008 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-19053753
13.
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 17(22): 6056-61, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17919905
Resultados
1 -
13
de 13
1
Próxima >
>>