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1.
Inhibition of vascular endothelial growth factor-a signaling induces hypertension: examining the effect of cediranib (recentin; AZD2171) treatment on blood pressure in rat and the use of concomitant antihypertensive therapy.
Clin Cancer Res
; 14(10): 3124-31, 2008 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18483380
2.
The use and refinement of rodent models in anti-cancer drug discovery: a review.
Altern Lab Anim
; 37(2): 173-80, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19453212
3.
Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer.
Mol Cancer Ther
; 17(5): 908-920, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29483206
4.
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer.
Cancer Res
; 65(10): 4389-400, 2005 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15899831
5.
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.
Cancer Res
; 62(16): 4645-55, 2002 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-12183421
6.
Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J Med Chem
; 59(10): 4859-66, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27078757
7.
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Cancer Res
; 76(11): 3307-18, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27020862
8.
In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib.
Pharmacol Res Perspect
; 3(5): e00175, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26516587
9.
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.
J Med Chem
; 58(20): 8128-40, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26407012
10.
Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.
J Med Chem
; 45(6): 1300-12, 2002 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11881999
11.
Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats.
J Natl Cancer Inst
; 99(22): 1724-8, 2007 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-18000220
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