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1.
An integrated Qual/Quan strategy for ganglioside lipidomics using high-resolution mass spectrometry and Skyline software.
Rapid Commun Mass Spectrom
; 35(7): e9041, 2021 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33415785
2.
Fucosyl monosialoganglioside: Quantitative analysis of specific potential biomarkers of lung cancer in biological matrices using immunocapture extraction/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 32(17): 1481-1490, 2018 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29876976
3.
Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg Med Chem Lett
; 28(2): 85-93, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29233651
4.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055941
5.
Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.
Anal Chem
; 86(23): 11523-7, 2014 Dec 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-25371986
6.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200244
7.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200252
8.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23200249
9.
Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1207: 123305, 2022 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35839627
10.
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett
; 12(7): 1143-1150, 2021 Jul 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34267885
11.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett
; 11(11): 2195-2203, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214829
12.
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
J Med Chem
; 62(20): 8953-8972, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31314518
13.
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
J Med Chem
; 62(20): 8973-8995, 2019 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31318208
14.
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
ACS Med Chem Lett
; 10(3): 383-388, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891145
15.
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
Sci Transl Med
; 11(502)2019 07 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-31341059
16.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem
; 62(5): 2265-2285, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30785748
17.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem
; 62(7): 3228-3250, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30893553
18.
The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.
J Pharmacol Exp Ther
; 324(2): 576-86, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17986646
19.
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).
J Med Chem
; 51(6): 1976-80, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18288793
20.
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Bioorg Med Chem Lett
; 18(9): 2985-9, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18395443