Detalles de la búsqueda
1.
Synthesis of 1,2,4-Triazinones Exploiting the Reactivity of Diazadiene and N-Isocyanate Intermediates.
J Org Chem
; 88(4): 2095-2102, 2023 Feb 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36749643
2.
Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2220579, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37288786
3.
A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.
Drug Dev Res
; 84(6): 1247-1265, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37232504
4.
Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers.
J Enzyme Inhib Med Chem
; 37(1): 1587-1599, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35637622
5.
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies.
J Enzyme Inhib Med Chem
; 37(1): 397-410, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34961427
6.
Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation.
J Enzyme Inhib Med Chem
; 37(1): 2063-2077, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35875937
7.
New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies.
J Enzyme Inhib Med Chem
; 37(1): 2191-2205, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35975321
8.
Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation.
Molecules
; 27(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35956997
9.
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies.
Bioorg Med Chem
; 46: 116384, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34479065
10.
New bis([1,2,4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation.
Bioorg Chem
; 112: 104949, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34023640
11.
Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site.
Bioorg Chem
; 112: 104965, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34020238
12.
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis.
Bioorg Chem
; 110: 104807, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33721808
13.
New Thieno[2,3-d]pyrimidines as Anticancer VEGFR-2 Inhibitors with Apoptosis Induction: Design, Synthesis, and Biological and In Silico Studies.
Med Chem
; 2024 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-38798211
14.
Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket.
J Biomol Struct Dyn
; 42(5): 2369-2391, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-37129193
15.
Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies.
Heliyon
; 10(2): e24005, 2024 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38298627
16.
New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies.
Biochim Biophys Acta Gen Subj
; 1868(6): 130599, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38521471
17.
Discovery of new thieno[2,3-d]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment.
Future Med Chem
; 15(13): 1167-1184, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37529910
18.
New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations.
Future Med Chem
; 15(14): 1233-1250, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37466069
19.
New thiazolidine-2,4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity studies.
Comput Biol Chem
; 107: 107958, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37714080
20.
Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations.
J Biomol Struct Dyn
; : 1-20, 2023 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37261471