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1.
Population pharmacokinetics of serelaxin in patients with acute or chronic heart failure, hepatic or renal impairment, or portal hypertension and in healthy subjects.
Br J Clin Pharmacol
; 84(11): 2572-2585, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30014598
2.
Proportional pulse pressure relates to cardiac index in stabilized acute heart failure patients.
Clin Exp Hypertens
; 40(7): 637-643, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29265934
3.
Pharmacokinetics of serelaxin in patients with hepatic impairment: a single-dose, open-label, parallel group study.
Br J Clin Pharmacol
; 79(6): 937-45, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25511105
4.
A randomized, double-blind, placebo-controlled, multicentre study to assess haemodynamic effects of serelaxin in patients with acute heart failure.
Eur Heart J
; 35(7): 431-41, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-24255129
5.
Design and Rationale of the APPELHUS Phase 3 Open-Label Study of Factor B Inhibitor Iptacopan for Atypical Hemolytic Uremic Syndrome.
Kidney Int Rep
; 8(7): 1332-1341, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37441479
6.
Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
Eur J Clin Pharmacol
; 68(5): 697-708, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22124880
7.
Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension.
J Am Soc Hypertens
; 11(8): 488-497, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28666704
8.
Pharmacokinetics of serelaxin in patients with severe renal impairment or end-stage renal disease requiring hemodialysis: A single-dose, open-label, parallel-group study.
J Clin Pharmacol
; 56(4): 474-83, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26239266
9.
Pharmacokinetic drug-drug interaction assessment of LCZ696 (an angiotensin receptor neprilysin inhibitor) with omeprazole, metformin or levonorgestrel-ethinyl estradiol in healthy subjects.
Clin Pharmacol Drug Dev
; 5(1): 27-39, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27119576
10.
Safety and tolerability of serelaxin, a recombinant human relaxin-2 in development for the treatment of acute heart failure, in healthy Japanese volunteers and a comparison of pharmacokinetics and pharmacodynamics in healthy Japanese and Caucasian populations.
J Clin Pharmacol
; 55(4): 415-22, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25408331
11.
Renal hemodynamic effects of serelaxin in patients with chronic heart failure: a randomized, placebo-controlled study.
Circ Heart Fail
; 7(6): 994-1002, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25286914
12.
Aliskiren penetrates adipose and skeletal muscle tissue and reduces renin-angiotensin system activity in obese hypertensive patients.
J Hypertens
; 30(3): 561-6, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22278138
13.
Effect of verapamil on the pharmacokinetics of aliskiren in healthy participants.
J Clin Pharmacol
; 51(2): 218-28, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20413453
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