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1.
Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment.
Bioorg Med Chem
; 79: 117150, 2023 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36640594
2.
Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.
Eur J Med Chem
; 239: 114522, 2022 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35749987
3.
Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore.
J Med Chem
; 65(5): 4270-4290, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35188773
4.
Palladium-catalyzed, stereoselective, cyclizative alkenylboration of carbon-carbon double bonds through activation of a boron-chlorine bond.
J Am Chem Soc
; 133(13): 4758-61, 2011 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-21391594
5.
LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
Sci Adv
; 7(11)2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33712455
6.
Inhibition of KDM1A activity restores adult neurogenesis and improves hippocampal memory in a mouse model of Kabuki syndrome.
Mol Ther Methods Clin Dev
; 20: 779-791, 2021 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33738331
7.
Palladium-catalyzed carboboration of alkynes using chloroborane and organozirconium reagents.
Chem Commun (Camb)
; (41): 5224-6, 2008 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-18956076
8.
Palladium-catalyzed trans- and cis-carboboration of alkynes tethered to chloroborane with organozirconium reagents: ligand-dependent complementary stereoselectivity.
J Am Chem Soc
; 130(10): 2918-9, 2008 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-18278920
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