Detalles de la búsqueda
1.
Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents.
Molecules
; 29(2)2024 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38276593
2.
C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug.
Molecules
; 28(2)2023 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36677739
3.
Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation.
Molecules
; 28(1)2022 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615267
4.
Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease.
Br J Clin Pharmacol
; 87(7): 2830-2837, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33274491
5.
Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer's Disease Treatment through Rigidification Strategy.
Molecules
; 26(9)2021 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33926141
6.
First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease.
Molecules
; 26(1)2020 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-33375412
7.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Neurobiol Dis
; 129: 217-233, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30928644
8.
A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth.
BMC Plant Biol
; 19(1): 152, 2019 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31010418
9.
Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.
Molecules
; 24(15)2019 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-31370232
10.
Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.
Proc Natl Acad Sci U S A
; 111(36): E3825-30, 2014 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25157130
11.
Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles.
Bioorg Med Chem Lett
; 24(2): 467-72, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24374274
12.
Synthesis and interest in medicinal chemistry of ß-phenylalanine derivatives (ß-PAD): an update (2010-2022).
Future Med Chem
; 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38722231
13.
Discovery of a pocket network on the domain 5 of the TrkB receptor - A potential new target in the quest for the new ligands.
Mol Inform
; : e202400043, 2024 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38619318
14.
A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity.
Cell Death Dis
; 15(5): 311, 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38697987
15.
Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy.
Nat Commun
; 15(1): 4175, 2024 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-38755132
16.
Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer's Disease.
Pharmaceutics
; 15(10)2023 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37896142
17.
Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor.
Eur J Med Chem
; 248: 115111, 2023 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36645981
18.
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Bioorg Med Chem
; 20(8): 2614-23, 2012 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22429510
19.
Advances in prodrug design for Alzheimer's disease: the state of the art.
Expert Opin Drug Discov
; 17(4): 325-341, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35089846
20.
Desirable drug-drug interactions or when a matter of concern becomes a renewed therapeutic strategy.
Drug Discov Today
; 26(2): 315-328, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33253919