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1.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Regul Toxicol Pharmacol
; 138: 105329, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36592682
2.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Regul Toxicol Pharmacol
; 138: 105339, 2023 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-36649820
3.
Harmonized 3Rs-based non-mutagenic impurity qualification study designs developed using the results of an IQ consortium survey.
Regul Toxicol Pharmacol
; 122: 104895, 2021 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-33610610
4.
Computational requirements for real-time ptychographic image reconstruction.
Appl Opt
; 58(7): B19-B27, 2019 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30874231
5.
Beyond MABEL: An Integrative Approach to First in Human Dose Selection of Immunomodulators by the Health and Environmental Sciences Institute (HESI) Immuno-Safety Technical Committee (ITC).
Clin Pharmacol Ther
; 2024 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38847597
6.
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Bioorg Med Chem Lett
; 17(23): 6529-34, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17935984
7.
Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.
Toxicology
; 335: 11-9, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26134581
8.
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.
J Med Chem
; 53(11): 4422-7, 2010 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-20462217
9.
Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase.
Chem Res Toxicol
; 20(12): 1871-7, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18001061
10.
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
J Biol Chem
; 282(38): 27781-91, 2007 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-17623656
11.
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Bioorg Med Chem Lett
; 16(22): 5822-6, 2006 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16942871
12.
Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications.
Chem Res Toxicol
; 15(2): 180-6, 2002 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-11849044
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