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1.
Evaluating the Impact of the Tyr158 pKa on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis.
Biochemistry
; 62(12): 1943-1952, 2023 06 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-37270808
2.
Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.
Biochemistry
; 56(13): 1865-1878, 2017 04 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28225601
3.
Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors.
J Am Chem Soc
; 139(9): 3417-3429, 2017 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28151657
4.
Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.
Biochemistry
; 55(21): 2992-3006, 2016 05 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-27136302
5.
Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy.
J Med Chem
; 66(11): 7454-7474, 2023 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37195170
6.
Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity.
J Med Chem
; 65(24): 16510-16525, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36459397
7.
A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure.
ACS Infect Dis
; 7(4): 746-758, 2021 04 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33710875
8.
Correlating Drug-Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability.
ACS Infect Dis
; 6(4): 629-636, 2020 04 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32011855
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