Detalles de la búsqueda
1.
Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics.
Drug Metab Dispos
; 2024 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38641346
2.
Functional and structural insight into the flexibility of cytochrome P450 reductases from Sorghum bicolor and its implications for lignin composition.
J Biol Chem
; 298(4): 101761, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35202651
3.
Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase from Sorghum bicolor.
Plant Physiol
; 183(3): 957-973, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32332088
4.
Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics.
Arch Biochem Biophys
; 708: 108937, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34058150
5.
Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4.
Arch Biochem Biophys
; 698: 108677, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33197431
6.
Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate.
Xenobiotica
; 50(12): 1393-1405, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32662751
7.
Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2.
Biochem J
; 476(23): 3661-3685, 2019 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31750875
8.
Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences.
Biochem J
; 474(20): 3523-3542, 2017 10 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28904078
9.
Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy.
Biophys J
; 110(7): 1485-1498, 2016 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27074675
10.
Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences.
J Biol Chem
; 290(6): 3850-64, 2015 Feb 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25533469
11.
Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.
Biochemistry
; 54(3): 711-21, 2015 Jan 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25545162
12.
The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.
Arch Biochem Biophys
; 545: 100-7, 2014 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24445070
13.
Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone.
Biochem J
; 453(2): 219-30, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23651100
14.
Effects of alcohol consumption and tobacco smoking on the composition of the ensemble of drug metabolizing enzymes and transporters in human liver.
bioRxiv
; 2024 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38798409
15.
Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET).
J Biol Chem
; 287(9): 6797-809, 2012 Feb 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22194603
16.
CYP261 enzymes from deep sea bacteria: a clue to conformational heterogeneity in cytochromes P450.
Biotechnol Appl Biochem
; 60(1): 30-40, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23586990
17.
Aluminum-substituted heme domain of P450BM-3 (BMP): introducing a heme-derived fluorescent probe for studies of substrate binding and protein-protein interactions in cytochromes P450.
Biotechnol Appl Biochem
; 60(1): 41-51, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23586991
18.
High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism.
Biology (Basel)
; 12(8)2023 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37626940
19.
Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy.
Biology (Basel)
; 11(4)2022 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35453709
20.
Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry.
Biomolecules
; 12(2)2022 01 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-35204686