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1.
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function.
Proc Natl Acad Sci U S A
; 120(4): e2212338120, 2023 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36649421
2.
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels.
Mol Pharmacol
; 105(3): 202-212, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38302135
3.
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Bioorg Med Chem Lett
; 87: 129256, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36966977
4.
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels.
Mol Pharmacol
; 101(5): 357-370, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35246480
5.
Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators.
Lett Drug Des Discov
; 16(12): 1387-1394, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32201485
6.
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992.
Mol Pharmacol
; 94(2): 926-937, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29895592
7.
Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias.
J Biol Chem
; 287(47): 39613-25, 2012 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23033485
8.
Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen.
Assay Drug Dev Technol
; 21(3): 89-96, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36930852
9.
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Mol Pharmacol
; 81(2): 120-33, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22021324
10.
Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.
Bioorg Med Chem Lett
; 22(20): 6481-5, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22981332
11.
Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2.
Proc Natl Acad Sci U S A
; 106(13): 5383-8, 2009 Mar 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-19279215
12.
Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.
Bioorg Med Chem Lett
; 21(9): 2697-701, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21194936
13.
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.
Mol Pharmacol
; 78(6): 1105-23, 2010 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-20923853
14.
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.
Mol Pharmacol
; 75(3): 577-88, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19047481
15.
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Mol Pharmacol
; 74(5): 1345-58, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18664603
16.
Screening for AMPA receptor auxiliary subunit specific modulators.
PLoS One
; 12(3): e0174742, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28358902
17.
Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.
ACS Chem Neurosci
; 8(3): 558-568, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27805811
18.
Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core.
J Med Chem
; 60(4): 1611-1616, 2017 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28103022
19.
An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria.
Sci Rep
; 6: 36954, 2016 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27849039
20.
Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly.
J Neuroimmunol
; 166(1-2): 88-101, 2005 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16024094