Detalles de la búsqueda
1.
Species differences in small intestinal exposure-related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule.
J Appl Toxicol
; 44(3): 400-414, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-37814191
2.
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.
Regul Toxicol Pharmacol
; : 105334, 2023 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36608923
3.
Opinion on Maintaining In-House GLP Status for Toxicologic Pathology in Pharmaceutical and (Agro)Chemical Development.
Toxicol Pathol
; 50(1): 147-152, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34433323
4.
Comparison of the Local Tolerability to 5 Long-acting Drug Nanosuspensions with Different Stabilizing Excipients, Following a Single Intramuscular Administration in the Rat.
Toxicol Pathol
; 46(1): 85-100, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29096596
5.
Biopsy Pathology and Immunohistochemistry of a Case of Immune-Mediated Drug-Induced Liver Injury With Atabecestat.
Hepatology
; 73(1): 452-455, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32488886
6.
Dose- and Time-dependency of the Toxicity and Pharmacokinetic Profiles of Bedaquiline and Its N-desmethyl Metabolite in Dogs.
Toxicol Pathol
; 45(5): 663-675, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28789609
7.
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
J Virol
; 89(9): 4809-17, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25673700
8.
Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.
Toxicol Pathol
; 44(2): 189-210, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26698322
9.
Successful integration of nonclinical and clinical findings in interpreting the clinical relevance of rodent neoplasia with a new chemical entity.
Toxicol Pathol
; 43(1): 48-56, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25398756
10.
Bilateral Symmetrical Idiopathic Necrotizing Encephalopathy: A New Syndrome in Sprague-Dawley Rats.
Toxicol Pathol
; 43(8): 1141-8, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26511844
11.
Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.
Regul Toxicol Pharmacol
; 73(1): 210-26, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26188116
12.
Intravenous Administration of Ad26.COV2.S Does Not Induce Thrombocytopenia or Thrombotic Events or Affect SARS-CoV-2 Spike Protein Bioavailability in Blood Compared with Intramuscular Vaccination in Rabbits.
Vaccines (Basel)
; 11(12)2023 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38140195
13.
JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms.
Antiviral Res
; 196: 105196, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34718044
14.
Testing of acetaminophen in support of the international multilaboratory in vivo rat Pig-a assay validation trial.
Environ Mol Mutagen
; 61(5): 508-525, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32187737
15.
Hemorrhagic cardiomyopathy in male mice treated with an NNRTI: the role of vitamin K.
Toxicol Pathol
; 36(2): 321-9, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18367644
16.
Renal tubular and adrenal medullary tumors in the 2-year rat study with canagliflozin confirmed to be secondary to carbohydrate (glucose) malabsorption in the 15-month mechanistic rat study.
Chem Biol Interact
; 277: 85-90, 2017 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28916336
17.
Timing is everything for sperm assessment in fertility studies.
Reprod Toxicol
; 64: 141-50, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27181369
18.
The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.
J Control Release
; 230: 95-108, 2016 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27067365
19.
"All pigs are equal" Does the background data from juvenile Göttingen minipigs support this?
Reprod Toxicol
; 64: 105-15, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27112527
20.
Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection.
PLoS One
; 11(11): e0166094, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27812182