Detalles de la búsqueda
1.
Synthesis of 4-substituted chlorophthalazines, dihydrobenzoazepinediones, 2-pyrazolylbenzoic acid, and 2-pyrazolylbenzohydrazide via 3-substituted 3-hydroxyisoindolin-1-ones.
J Org Chem
; 77(8): 3887-906, 2012 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22458369
2.
Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase.
Bioorg Med Chem Lett
; 19(2): 424-7, 2009 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19062275
3.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18321037
4.
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Bioorg Med Chem Lett
; 18(3): 1172-6, 2008 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18083554
5.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16970394
6.
Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity.
J Med Chem
; 59(6): 2794-809, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26942860
7.
Lewis acid-mediated generation of bicyclo[5.3.0]decanes and bicyclo[4.3.0]nonanes.
Org Lett
; 7(26): 5785-8, 2005 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-16354066
8.
Discovery of N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), a highly selective, orally bioavailable inhibitor of aurora kinases with activity against multidrug-resistant cancer cell lines.
J Med Chem
; 58(13): 5189-207, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-25970324
9.
Discovery of potent and highly selective thienopyridine Janus kinase 2 inhibitors.
J Med Chem
; 54(24): 8440-50, 2011 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22087750
10.
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
J Med Chem
; 53(17): 6368-77, 2010 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-20684549
11.
Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Cancer Res
; 70(23): 9846-54, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20935223
12.
Intramolecular cyclobutadiene cycloaddition/cyclopropanation/thermal rearrangement: an effective strategy for the asymmetric syntheses of pleocarpenene and pleocarpenone.
J Am Chem Soc
; 129(3): 486-7, 2007 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-17227000
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