Detalles de la búsqueda
1.
Epigenetic programming underpins B cell dysfunction in human SLE.
Nat Immunol
; 20(8): 1071-1082, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31263277
2.
Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Proc Natl Acad Sci U S A
; 116(8): 3072-3081, 2019 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30718425
3.
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions.
Xenobiotica
; 49(8): 961-969, 2019 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-30124356
4.
Alkylsulfanyl analogs as potent α2δ ligands.
Bioorg Med Chem Lett
; 28(11): 2000-2002, 2018 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29752183
5.
The Comprehensive Characterization of B7-H3 Expression in the Tumor Microenvironment of Lung Squamous Cell Carcinoma: A Retrospective Study.
Cancers (Basel)
; 16(11)2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38893259
6.
Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.
Pharmacol Res Perspect
; 10(6): e01030, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36424908
7.
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.
Drug Metab Dispos
; 39(5): 820-9, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21282406
8.
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Bioorg Med Chem Lett
; 20(1): 341-5, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19926281
9.
Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].
Bioorg Med Chem Lett
; 20(2): 746-54, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20006498
10.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
Bioorg Med Chem Lett
; 19(15): 4159-66, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19541482
11.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Bioorg Med Chem Lett
; 19(15): 4151-8, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19540759
12.
Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells.
J Cereb Blood Flow Metab
; 23(4): 432-40, 2003 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-12679720
13.
Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Eur J Med Chem
; 45(11): 4788-96, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20801551
14.
Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier.
J Neurochem
; 96(4): 1051-9, 2006 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-16445853
15.
Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats.
Pharm Res
; 22(4): 619-27, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15846470
16.
Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats.
J Pharmacol Exp Ther
; 314(2): 932-8, 2005 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-15879000
17.
Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome.
Drug Metab Dispos
; 33(4): 596-602, 2005 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15640375
18.
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Kidney Int
; 61(5): 1760-8, 2002 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-11967025
19.
Characterization of uremic toxin transport by organic anion transporters in the kidney.
Kidney Int
; 65(1): 162-74, 2004 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-14675047
20.
Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat.
J Pharmacol Exp Ther
; 303(2): 880-7, 2002 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-12388676