Detalles de la búsqueda
1.
Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.
Bioorg Med Chem Lett
; 45: 128133, 2021 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34044121
2.
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.
Bioorg Med Chem Lett
; 21(16): 4773-8, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21763134
3.
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
J Med Chem
; 64(6): 2953-2966, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33682420
4.
Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179.
J Org Chem
; 75(5): 1643-51, 2010 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-20112997
5.
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.
Bioorg Med Chem Lett
; 20(2): 653-6, 2010 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19954970
6.
2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer.
Bioorg Med Chem Lett
; 19(17): 4980-3, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19640711
7.
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.
J Med Chem
; 62(21): 9618-9641, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31525968
8.
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
J Med Chem
; 62(8): 4091-4109, 2019 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30943032
9.
Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.
J Med Chem
; 62(2): 908-927, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30499663
10.
Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain.
Cell Rep
; 24(12): 3133-3145, 2018 09 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-30231997
11.
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 61(11): 4810-4831, 2018 06 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29737846
12.
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
J Med Chem
; 60(2): 767-786, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27983835
13.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
J Med Chem
; 60(13): 5521-5542, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28498658
14.
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
ACS Med Chem Lett
; 7(3): 277-82, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26985315
15.
Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines.
J Med Chem
; 46(5): 838-49, 2003 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-12593663
16.
Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010.
Pharm Pat Anal
; 3(5): 509-21, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25374320
17.
Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent phosphatidylinositol 3-kinase inhibitors.
J Med Chem
; 53(8): 3169-82, 2010 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20334367
18.
Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: discovery of PKI-402.
J Med Chem
; 53(2): 798-810, 2010 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-19968288
19.
Design and synthesis of novel diaminoquinazolines with in vivo efficacy for beta-catenin/T-cell transcriptional factor 4 pathway inhibition.
J Med Chem
; 53(2): 897-910, 2010 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-20025292
20.
Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.
J Med Chem
; 53(6): 2636-45, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20166697
Resultados
1 -
20
de 20
1
Próxima >
>>