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1.
Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Mol Pharmacol
; 97(1): 9-22, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31707355
2.
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Bioorg Med Chem
; 28(12): 115544, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32503687
3.
Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Bioorg Med Chem
; 27(23): 115125, 2019 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31679978
4.
Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer.
Mol Cancer Ther
; 23(6): 809-822, 2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38377173
5.
Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.
Mol Cancer Ther
; 19(11): 2245-2255, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32879053
6.
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Mol Cancer Ther
; 18(10): 1787-1799, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31289137
7.
Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Mol Cancer Ther
; 22(2): 287, 2023 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36602953
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