Detalles de la búsqueda
1.
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation.
Bioorg Med Chem
; 22(7): 2194-207, 2014 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24630695
2.
Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: some structural aspects for aldose reductase inhibitory activity and selectivity.
Bioorg Med Chem
; 21(4): 869-73, 2013 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23312612
3.
Glutathione-Hemin/Hematin Adduct Formation to Disintegrate Cytotoxic Oxidant Hemin/Hematin in Human K562 Cells and Red Blood Cells' Hemolysates: Impact of Glutathione on the Hemolytic Disorders and Homeostasis.
Antioxidants (Basel)
; 11(10)2022 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-36290682
4.
Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity.
Bioorg Med Chem
; 19(4): 1426-33, 2011 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21288726
5.
Drug-like Properties and Fraction Lipophilicity Index as a combined metric.
ADMET DMPK
; 9(3): 177-190, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35300360
6.
Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.
Bioorg Med Chem
; 18(6): 2107-2114, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20189816
7.
Formation of novel N-acetylcysteine-hemin adducts abrogates hemin-induced cytotoxicity and suppresses the NRF2-driven stress response in human pro-erythroid K562 cells.
Eur J Pharmacol
; 880: 173077, 2020 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32222495
8.
Aldose reductase enzyme and its implication to major health problems of the 21(st) century.
Curr Med Chem
; 16(6): 734-52, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19199934
9.
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors.
Bioorg Med Chem
; 16(7): 3926-32, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18267362
10.
Permeability characteristics of novel aldose reductase inhibitors using rat jejunum in vitro.
Eur J Pharm Sci
; 28(1-2): 128-33, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16497491
11.
Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.
J Med Chem
; 46(3): 417-26, 2003 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-12540241
12.
[1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone as a bioisostere of a carboxylic acid aldose reductase inhibitor.
J Med Chem
; 47(10): 2706-9, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115413
13.
Development of aldose reductase inhibitors for the treatment of inflammatory disorders.
Expert Opin Drug Discov
; 8(11): 1365-80, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-24090200
14.
Novel aldose reductase inhibitors: a patent survey (2006--present).
Expert Opin Ther Pat
; 22(11): 1303-23, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22998509
15.
Bis-pyrrolyl-tetrazolyl derivatives as hybrid polar compounds: A case of lipophilic functional bioisosterism with bis-acetamides.
Eur J Med Chem
; 50: 75-80, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22341896
16.
A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity.
J Med Chem
; 53(21): 7756-66, 2010 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20936791
17.
Nutritional overview on the management of type 2 diabetes and the prevention of its complications.
Curr Diabetes Rev
; 6(6): 400-9, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20879970
18.
HPLC-based lipophilicity of pyrrolyl-acetic acid ARIs: Relationships with biological activity.
J Chromatogr B Analyt Technol Biomed Life Sci
; 878(1): 61-7, 2010 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19948428
19.
Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.
Eur J Med Chem
; 45(4): 1663-6, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20071057
20.
Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum.
Bioorg Med Chem
; 14(5): 1653-9, 2006 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16249088