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1.
Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses.
J Vet Pharmacol Ther
; 44(4): 533-543, 2021 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-33576078
2.
Variability and Lability of Ammonia Levels in Healthy Volunteers and Patients With Cirrhosis: Implications for Trial Design and Clinical Practice.
Am J Gastroenterol
; 115(5): 783-785, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31449156
3.
Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects.
Br J Clin Pharmacol
; 83(2): 326-338, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27621150
4.
Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.
Br J Clin Pharmacol
; 79(5): 831-7, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25377933
5.
Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.
Drug Metab Dispos
; 42(11): 1926-39, 2014 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25142735
6.
An updated Alzheimer's disease progression model: incorporating non-linearity, beta regression, and a third-level random effect in NONMEM.
J Pharmacokinet Pharmacodyn
; 41(6): 581-98, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25168488
7.
Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study.
Front Neurosci
; 18: 1302714, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38362023
8.
The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers.
Cell Host Microbe
; 32(3): 382-395.e10, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309259
9.
Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial.
Nat Metab
; 5(10): 1685-1690, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37770764
10.
Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.
PLoS Comput Biol
; 6(9)2010 Sep 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-20941387
11.
Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria.
Commun Biol
; 4(1): 898, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34294862
12.
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study.
Nat Metab
; 3(8): 1125-1132, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34294923
13.
Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).
Br J Clin Pharmacol
; 69(1): 15-22, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20078608
14.
AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients.
Cell Rep Med
; 1(4): 100057, 2020 07 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33205064
15.
Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs.
Eur J Pain
; 23(6): 1129-1140, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30793411
16.
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans.
Sci Transl Med
; 11(475)2019 01 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30651324
17.
Translational Development of Microbiome-Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates.
Clin Transl Sci
; 11(2): 200-207, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29194983
18.
Publisher Correction: Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study.
Nat Metab
; 4(9): 1214, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35974248
19.
Glycemic Effect and Safety of a Systemic, Partial Glucokinase Activator, PF-04937319, in Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin-A Randomized, Crossover, Active-Controlled Study.
Clin Pharmacol Drug Dev
; 5(6): 517-527, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27870481
20.
A semi-mechanistic model for the effects of a novel glucagon receptor antagonist on glucagon and the interaction between glucose, glucagon, and insulin applied to adaptive phase II design.
AAPS J
; 16(6): 1259-70, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25160589